Multiple Sclerosis: In The War Against Diseases, Nerve Cells Need Their Armor

ScienceDaily (Nov. 14, 2008) — In a new study, researchers at the Montreal Neurological Institute (MNI), McGill University, and the Université de Montréal have discovered an essential mechanism for the maintenance of the normal structure of myelin, the protective covering that insulates and supports nerve cells (neurons). Up until now, very little was known about myelin maintenance.

This new information provides vital insight into diseases such as Multiple Sclerosis (MS) and other progressive demyelinating diseases in which myelin is destroyed, causing irreversible damage and disrupting the nerve cells' ability to transmit messages. The research, published recently in the Journal of Neuroscience, is the first to identify a role for the protein netrin-1, previously characterized only in the developing nervous system, with this critical function in the adult nervous system.

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Riken Researchers Make Brain Tissues from Stem Cells

Japanese researchers said Thursday they had created functioning human brain tissues from stem cells, a world first that has raised new hopes for the treatment of disease. Stem cells taken from human embryos have been used to form tissues of the cerebral cortex, the supreme control tower of the brain, according to researchers at the government-backed research institute Riken.

The research was led by Yoshiki Sasai at Riken Center for Development Biology in Kobe.

The tissues self-organized into four distinct zones very similar to the structure seen in human fetuses, and conducted neuro-activity such as transmitting electrical signals, the institute said.

Research on stem cells is seen as having the potential to save lives by helping to find cures for diseases such as cancer and diabetes or to replace damaged cells, tissues and organs.

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Film looks at disability perceptions, reality

Portland News-If you had to have a disability, which one would you choose?

That's the question posed by the documentary "Disabled Lives," directed by four Portland-area teens as part of Film Action Oregon's Project Youth Doc.

"We interviewed people all over the city — Waterfront Park, Hollywood Theatre, Pioneer Square, OHSU, Grant Park," says Nate Higby, one of the filmmakers. "Most of the people we asked were willing to talk with us, but a lot of them had trouble answering that question."

One young man in the film responds, "I don't want any disabilities." Another, after stalling, says he would choose the one that is "the least visible."

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Brain Implants May Help Stroke Patients Overcome Partial Paralysis

ScienceDaily (Nov. 11, 2008) — Scientists have shown for the first time that neuroprosthetic brain implants may be able to help stroke patients with partial paralysis.

Researchers found that implants known as brain-computer interfaces (BCI) may be able to detect activity on one side of the brain that is linked to hand and arm movements on the same side of the body. They hope to use these signals to guide motorized assistance mechanisms that restore mobility in partially paralyzed limbs.

Partial paralysis on one side of the body results from stroke damage to the opposite side of the brain. This fits with the conventional model of how the brain controls movement, which says signals in one half of the brain control the opposite half of the body. That model led scientists to assume that stroke damage would make it impossible for BCIs to pick up any useful movement control signals from the brain and restore function in the body's paralyzed half.

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Can Vitamins And Minerals Prevent Hearing Loss?

ScienceDaily (Nov. 10, 2008) — About 10 million people in the United States alone—from troops returning from war to students with music blasting through headphones—are suffering from impairing noise-induced hearing loss.

The rising trend is something that researchers and physicians at the University of Michigan Kresge Hearing Research Institute are hoping to reverse, with a cocktail of vitamins and the mineral magnesium that has shown promise as a possible way to prevent hearing loss caused by loud noises. The nutrients were successful in laboratory tests, and now researchers are testing whether humans will benefit as well.

The prevention of noise induced hearing loss is key," says Glenn E. Green, M.D., assistant professor of otolaryngology at the U-M Health System and director of the U-M Children's Hearing Laboratory.

"When we can't prevent noise-induced hearing loss through screening programs and use of hearing protection, then we really need to come up with some way of protecting people who are still going to have noise exposure. My hope is that this medication will give people a richer, fuller life."

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Autism Gene Linked to Childhood Language Disorder

LONDON (Reuters) – A gene linked to autism may also play a role in the most common childhood language disorder, researchers said on Wednesday, perhaps explaining why some children develop language difficulties.

"This is the first time anyone has pinpointed a specific gene that is involved in common forms of language impairments," University of Oxford geneticist and Wellcome Trust researcher Simon Fisher, who led the study, said in a telephone interview.

The condition known as specific language impairment affects an estimated 2-7 percent of pre-school children and is as common as dyslexia, Fisher said.

The starting point for the study was a different gene called FOXP2 that regulates other genes and appears to play a role in a severe but rare form of speech and language disorder.

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Head Injury in Young Kids May Predict ADHD Diagnosis

THURSDAY, Nov. 6 (HealthDay News) -- Very young children who sustain a head injury may be more likely to be diagnosed with attention-deficit hyperactivity disorder (ADHD) later, researchers report.

The head injury is not a cause of ADHD, but rather a result of excessive risk-taking, according to the paper published in the Nov. 8 online edition of the British Medical Journal.

"There have been studies done that link moderate to severe traumatic brain injury in older children to ADHD," said lead researcher Dr. Heather Keenan, an associate professor of pediatrics at the University of Utah in Salt Lake City. "There has been some suggestion that mild traumatic brain injury could also be linked to ADHD."

The researchers wanted to know whether or not head injury that occurs before the age of 2 might cause ADHD. A diagnosis of ADHD cannot be made before that age, Keenan noted.

"It is hard to figure this out, because we don't know whether or not the kids would have gone on to develop ADHD regardless of the head injury," Keenan said.

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Brain Injury Repair? Damaged Nerves Regenerated By Silencing Natural Growth Inhibitors In Neurons

ScienceDaily (Nov. 7, 2008) — Silencing natural growth inhibitors may make it possible to regenerate nerves damaged by brain or spinal cord injury, finds a study from Children's Hospital Boston. In a mouse study published in the November 7 issue of Science, researchers temporarily silenced genes that prevent mature neurons from regenerating, and caused them to recover and re-grow vigorously after damage.

Because injured neurons cannot regenerate, there is currently no treatment for spinal cord or brain injury, says Zhigang He, PhD, Associate Professor of Neurology at Children's and senior author on the paper. Previous studies that looked at removing inhibitory molecules from the neurons' environment, including some from He's own lab, have found only modest effects on nerve recovery. But now He's team, in collaboration with Mustafa Sahin, MD, PhD, Assistant Professor of Neurology at Children's, demonstrates that re-growth is primarily regulated from within the cells themselves.

"We knew that on completion of development, cells stop growing due to genetic mechanisms that prevent overgrowth," explains He. "We thought that this kind of mechanism might also prevent regeneration after injury."

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Multiple Sclerosis Progression Can Be Predicted With MRI

ScienceDaily (Nov. 6, 2008) — A new study published in Journal of Neuroimaging shows that MRI scans used on multiple sclerosis (MS) patients to determine if the disease has affected gray matter in the brain can identify those at-risk for progression of disability.

MS affects approximately 400,000 people in the United States and as many as 2.5 million worldwide. It is the most common cause of progressive disability in young adults. While the cause of the disease remains unknown, it is characterized by damage to the covering over the nerve fibers in the brain and spinal cord, or to the nerve fiber itself.

In an attempt to understand the causes of disease progression, researchers at the Partners MS Center, led by Dr. Rohit Bakshi and his team, have developed new ways to detect gray matter damage.

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Is ADHD More Likely To Affect Movement In Boys Or Girls?

ScienceDaily (Nov. 5, 2008) — Attention deficit hyperactivity disorder (ADHD) appears to affect movement in boys more than it does in girls, according to a new study. ADHD is one of the most common mental disorders found in children. Symptoms include impulsiveness, hyperactivity, such as not being able to sit still, and inattention or constant daydreaming. Few studies have been done that compare ADHD and movement in both boys and girls.

Researchers tested the movement abilities of 132 boys and girls with ADHD and 136 without the disorder. The children were between the ages of seven and 15 years and were tested for how fast and how well they could tap their toes, walk on their heels, maintain balance and keep a steady rhythm during a task compared to scores typical for their age.

The study found that girls with ADHD and the control group of children without ADHD were twice as likely to be able to control their movements for their age compared to boys with ADHD, who showed continued difficulties.

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Autism Linked with Rainfall in Study

WASHINGTON (Reuters) – Children who live in the U.S. Northwest's wettest counties are more likely to have autism, but it is unclear why, U.S. researchers reported on Tuesday.

Michael Waldman of Cornell University and colleagues were searching for an environmental link with autism, a condition characterized by learning and social disabilities.

They got autism rates from state and county agencies for children born in California, Oregon and Washington between 1987 and 1999 and plotted them against daily precipitation reports.

"Autism prevalence rates for school-aged children in California, Oregon and Washington in 2005 were positively related to the amount of precipitation these counties received from 1987 through 2001," they wrote in the Archives of Pediatrics & Adolescent Medicine.

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Interferon Could Be A Key To Preventing Or Treating Multiple Sclerosis

ScienceDaily (Nov. 1, 2008) — Multiple sclerosis (MS) results when the body's own defense system attacks nerve fibers in the brain and spinal cord. Now scientists led by John Russell, Ph.D., at Washington University School of Medicine in St. Louis have shown that interferon-gamma plays a deciding role in whether immune cells attack and injure the central nervous system (brain and spinal cord) in mice.

Interferon-gamma is an immune system protein that helps the body defend itself from invaders. In their latest research, which appeared in the October issue of the Journal of Experimental Medicine, the researchers show that interferon-gamma determined whether activated immune cells — previously primed to go after nerve cells — would actually cause nerve damage in experimental mice.

The researchers found that in the cerebellums and brainstems of the mice, interferon-gamma was protective. However, in the spinal cord, interferon-gamma had the opposite effect, permitting nerve cell damage.

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Gene Find Sheds Light On Motor Neuron Diseases Like ALS

ScienceDaily (Oct. 27, 2008) — Scientists have identified a gene in mice that plays a central role in the proper development of one of the nerve cells that goes bad in amyotrophic lateral sclerosis, or Lou Gehrig's disease, and some other diseases that affect our motor neurons.

The study is the result of a collaboration by scientists at the University of Rochester Medical Center who normally focus on the eye, working together with a developmental neuroscientist at Harvard who focuses on the cerebral cortex. The work appears in the Oct. 23 issue of the journal Neuron.

The work centers on corticospinal neurons, crucial nerve cells that connect the brain to the spinal cord. These neurons degenerate in patients with ALS, and their injury can play a central role in spinal cord injury as well. These are the longest nerves in the central nervous system – nerves sometimes several feet long that run from the brain to the spinal cord. As the ends of the nerves degenerate, patients lose the ability to control their muscles.

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