Monday, April 30, 2012

Actor Noah Wyle, Disability Advocates Arrested In DC Protest


Disability Scoop (April 23, 2012)-Dozens of disability advocates — including actor Noah Wyle — were arrested Monday on the grounds of the U.S. Capitol while protesting possible changes to Medicaid.

The activists — many in wheelchairs — were participating in a demonstration organized by the disability rights group ADAPT. Members of the organization positioned themselves in the rotunda of the Cannon House Office Building and refused to leave prompting the arrests, according to ADAPT representatives.

Officials with the U.S. Capitol Police said they arrested 76 individuals at the protest who were charged with unlawful conduct and demonstrating in the Capitol.

Members of ADAPT say they are speaking out amid a “dire national Medicaid crisis.” Specifically, the group opposes a Republican plan to cut federal Medicaid funding and favors an elimination of the so-called “institutional bias” whereby states provide nursing care to individuals with disabilities in institutional settings, but often are not required to offer similar assistance in the community.

“Cutting or changing Medicaid without thoughtful reform has very real life or death consequences for people with disabilities and people who are aging who live on fixed incomes that are significantly below the poverty level,” said Marsha Katz who traveled from Montana to participate in the ADAPT actions. “Washington should be putting our tax dollars into cost-saving community based services, not costly nursing homes and institutions.”

Wyle, who is best known for appearing on NBC’s “ER” and is a vocal advocate for universal health care, joined the protesters and was among those detained.

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Friday, April 27, 2012

Strong Support for Once-Marginalized Theory On Parkinson’s Disease


ScienceDaily (Apr. 25, 2012) University of California, San Diego scientists have used powerful computational tools and laboratory tests to discover new support for a once-marginalized theory about the underlying cause of Parkinson's disease.

The new results conflict with an older theory that insoluble intracellular fibrils called amyloids cause Parkinson's disease and other neurodegenerative diseases. Instead, the new findings provide a step-by-step explanation of how a "protein-run-amok" aggregates within the membranes of neurons and punctures holes in them to cause the symptoms of Parkinson's disease.

The discovery, published in the March 2012 issue of the FEBS Journal, describes how α-synuclein (a-syn), can turn against us, particularly as we age. Modeling results explain how α-syn monomers penetrate cell membranes, become coiled and aggregate in a matter of nanoseconds into dangerous ring structures that spell trouble for neurons.

"The main point is that we think we can create drugs to give us an anti-Parkinson's effect by slowing the formation and growth of these ring structures," said Igor Tsigelny, lead author of the study and a research scientist at the San Diego Supercomputer Center and Department of Neurosciences, both at UC San Diego.

Familial Parkinson's disease is caused in many cases by a limited number of protein mutations. One of the most toxic is A53T. Tsigelny's team showed that the mutant form of α-syn not only penetrates neuronal membranes faster than normal α-syn, but the mutant protein also accelerates ring formation.

To read more about Pakinson's Disease, please click on the title.

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Thursday, April 26, 2012

How PCBs Promote Dendrite Growth, May Increase Autism Risk


ScienceDaily (Apr. 25, 2012) New research from UC Davis and Washington State University shows that PCBs, or polychlorinated biphenyls, launch a cellular chain of events that leads to an overabundance of dendrites -- the filament-like projections that conduct electrochemical signals between neurons -- and disrupts normal patterns of neuronal connections in the brain.

"Dendrite growth and branching during early development is a finely orchestrated process, and the presence of certain PCBs confuses the conductor of that process," said Pamela Lein, a developmental neurobiologist and professor of molecular biosciences in the UC Davis School of Veterinary Medicine. "Impaired neuronal connectivity is a common feature of a number of conditions, including autism spectrum disorders."

Reported April 24 in two related studies in the journal Environmental Health Perspectives, the findings underscore the developing brain's vulnerability to environmental exposures and demonstrate how PCBs could add to autism risk.

"We don't think PCB exposure causes autism," Lein said, "but it may increase the likelihood of autism in children whose genetic makeup already compromises the processes by which neurons form connections."

The senior authors of the studies were Lein and Isaac Pessah, chair of molecular biosciences in the School of Veterinary Medicine and director of the Center for Children's Environmental Health at UC Davis. Both are researchers with the UC Davis MIND Institute, which is dedicated to finding answers to autism and other neurodevelopmental disorders. The lead author was Gary Wayman of Washington State University's Program in Neuroscience, who first described the molecular pathway that controls the calcium signaling in the brain that guides normal dendrite growth.

To read more about PCBs and Autism, please click on the above title.

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Agent Reduces Autism-Like Behaviors in Mice: Boosts Sociability, Quells Repetitiveness


ScienceDaily (Apr. 25, 2012) National Institutes of Health researchers have reversed behaviors in mice resembling two of the three core symptoms of autism spectrum disorders (ASD). An experimental compound, called GRN-529, increased social interactions and lessened repetitive self-grooming behavior in a strain of mice that normally display such autism-like behaviors, the researchers say.

GRN-529 is a member of a class of agents that inhibit activity of a subtype of receptor protein on brain cells for the chemical messenger glutamate, which are being tested in patients with an autism-related syndrome. Although mouse brain findings often don't translate to humans, the fact that these compounds are already in clinical trials for an overlapping condition strengthens the case for relevance, according to the researchers.

"Our findings suggest a strategy for developing a single treatment that could target multiple diagnostic symptoms," explained Jacqueline Crawley, Ph.D., of the NIH's National Institute of Mental Health (NIMH). "Many cases of autism are caused by mutations in genes that control an ongoing process -- the formation and maturation of synapses, the connections between neurons. If defects in these connections are not hard-wired, the core symptoms of autism may be treatable with medications."

Crawley, Jill Silverman, Ph.D., and colleagues at NIMH and Pfizer Worldwide Research and Development, Groton, CT, report on their discovery April 25th, 2012 in the journal Science Translational Medicine.

To read more about Autism, please click the above title.

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Wednesday, April 25, 2012

South Carolina Youth Leadership Forum

YLF is Accepting Applications Through May 1st!

Students 17-21 years old are invited to attend the SC Youth Leadership Forum (YLF) on July 11-13, 2012 at Newberry College in Newberry, SC. This is a three-day program for SC students with disabilities who have demonstrated leadership potential in both their school and community. The leadership forum is designed to assist youth with disabilities in further developing leadership, citizenship, and social skills by using resources that can help them face challenges in becoming participating members of their communities.


There is no charge to attend YLF and all meals are provided. Students are responsible for providing their own transportation to and from Newberry College. More information and the application can be found at http://www.scvrd.net/i_ylf.html . The completed application packet must be postmarked by April 16, 2012. Please indicate what assistive technology accommodations (e.g. fm system, text-to-speech software, magnifier, or wheelchair) you use and will need during the forum.

The forum will include guest speakers, small and large group discussions, team-building activities, ropes course, mentor luncheon, and FUN!

For more information contact:

SC YLF

c/o PROParents

652 Bush River Road

Suite 203

Columbia, SC 29210

803-734-8028


The SC Youth Leadership Forum is implemented by state and local partners including PRO-parents, Inc., South Carolina Assistive Technology Program, South Carolina Vocational Rehabilitation Department, Continuum of Care, Wil Lou Gray Opportunity School, South Carolina Division of Career Development and Transition, South Carolina Developmental Disabilities Council and South Carolina Department of Education.

To access the CDR Library Catalog, please click on this link.

Tuesday, April 24, 2012

Literacy Supports Workshop


There is still space available in the following free workshop:

Literacy Supports

Date: April 25, 2012

Time: 9:00 – 11:00am

Presenter: Valeska Gioia, SC Department of Education AT Specialist
Location:
SC Assistive Technology Resource Center
Poplar Building, Midlands Center
8301 Farrow Road
Columbia, SC

Cost: Free

Overview of various free aids that can facilitate learning in any classroom and how many students with and without disabilities can benefit by incorporating these study aids into the daily curriculum. Text-to-speech, free and low-cost digital books, speech recognition, colored overlay and concept mapping software will be demonstrated.

Register for the Literacy Supports workshop online

For information about other assistive technology workshops, go to the SCATP Training page http://www.sc.edu/scatp/trainingschedule.html

To read more about the Literacy Supports Workshop, please click on the above title.

To access the CDR Library Catalog, please click on this link.

Microsoft 7 Accessibility


Date: May 2, 2012

Time: 9:00 – 11:00am

Presenter: Valeska Gioia, SC Department of Education AT Specialist

Location:
SC Assistive Technology Resource Center
Poplar Building, Midlands Center
8301 Farrow Road
Columbia, SC

Cost: Free

Learn how Microsoft 7 has improved their accessibility options with a totally interactive speech recognition program, an on-screen keyboard with several input methods and an improved magnification system. We will also review how other accessibility options can improve learning and computer access for students and demonstrate how to set up Microsoft accessibility options for individual students or for the entire class.

Register for the Microsoft 7 Accessibility workshop online
Link
For information about other assistive technology workshops, go to the SCATP Training page http://www.sc.edu/scatp/trainingschedule.html
To read more about Microsoft 7 accessibility, please click on the above title.
To access the CDR Library catalog, please click on this link.

Monday, April 23, 2012

New Stem Cell Found in Brain: Finding Could Be Key to Developing Methods to Heal and Repair Brain Injury and Disease

image of brain cell
ScienceDaily (Apr. 20, 2012) — "Researchers at Lund University in Sweden have discovered a new stem cell in the adult brain. These cells can proliferate and form several different cell types -- most importantly, they can form new brain cells. Scientists hope to take advantage of the finding to develop methods to heal and repair disease and injury in the brain.
Analyzing brain tissue from biopsies, the researchers for the first time found stem cells located around small blood vessels in the brain. The cell's specific function is still unclear, but its plastic properties suggest great potential.

"A similar cell type has been identified in several other organs where it can promote regeneration of muscle, bone, cartilage and adipose tissue," said Patrik Brundin, M.D., Ph.D., Jay Van Andel Endowed Chair in Parkinson's Research at Van Andel Research Institute (VARI), Head of the Neuronal Survival Unit at Lund University and senior author of the study.

In other organs, researchers have shown clear evidence that these types of cells contribute to repair and wound healing. Scientists suggest that the curative properties may also apply to the brain. The next step is to try to control and enhance stem cell self-healing properties with the aim of carrying out targeted therapies to a specific area of the brain.

"Our findings show that the cell capacity is much larger than we originally thought, and that these cells are very versatile," said Gesine Paul-Visse, Ph.D., Associate Professor of Neuroscience at Lund University and the study's primary author. "Most interesting is their ability to form neuronal cells, but they can also be developed for other cell types. The results contribute to better understanding of how brain cell plasticity works and opens up new opportunities to exploit these very features."

The study, published in the journal PLoS ONE, is of interest to a broad spectrum of brain research. Future possible therapeutic targets range from neurodegenerative diseases to stroke."

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Friday, April 20, 2012

South Carolina Roadmap to Developmental Screening

image of roadmap
The South Carolina Act Early team is pleased to provide the South Carolina Roadmap to Developmental Screening to people interested in developmental screening and services related to Autism Spectrum Disorders. The roadmap was developed by a team focused on collaboration among leaders representing professionals, state agencies, universities, health care systems, private organizations and families to improve quality of life for children and others with Autism Spectrum Disorders and their families.
The resource is intended as a guide that explains where to receive assistance for a child that may be at risk for an Autism Spectrum Disorder. It also provides an explanation of services, state agencies, assessments, and interventions relevant to this issue. Contact information for the key agencies and organizations is also provided.
You can see a PDF version of the roadmap by clicking on the title above. You can also download a copy from the following websites:

SC Department of Disabilities & Special Needs
http://www.ddsn.sc.gov

BabyNet
http://www.scfirststeps.org/BabyNet.html

USC Center for Disability Resources
http://uscm.med.sc.edu/cdrhome/index.asp

South Carolina Autism Society
http://www.scautism.org/roadmap.php

Greenville Hospital
http://www.ghschildrens.org/autism-­‐wonders-­‐home.php

Winston’s Wish Foundation
www.winstonswishfoundation.com

Team for Early Childhood Solutions
http://uscm.med.sc.edu/tecs/

SC Department of Education
http://ed.sc.gov

Family Connection of South Carolina
http://www.familyconnectionsc.org/

NOTE: To access the Center for Disability Resources Library, click on this link.

Thursday, April 19, 2012

In Breakthrough, Study Finds Cerebral Palsy Treatable


Disability Scoop (April 19, 2012)-Medication may be able to sharply alter the course of cerebral palsy, scientists said Wednesday, after finding that animals with the developmental condition responded remarkably to a new treatment.

Within five days of being given an anti-inflammatory drug, researchers found that newborn rabbits with cerebral palsy made dramatic progress. The animals were able to walk and hop, tasks they’d had great difficulty with prior to the treatment.

The findings, reported in the journal Science Translational Medicine, offer tremendous promise for people with the developmental disability, researchers said.

“This suggests that there is a window of opportunity to prevent cerebral palsy,” said Roberto Romero, chief of the Perinatology Research Branch of the National Institutes of Health and an author of the study.

For the study, researchers replicated in rabbits the brain inflammation often seen in people with cerebral palsy. They then used tiny molecules known as dendrimers to deliver an anti-inflammatory drug called N-acetyl-L-cysteine, or NAC, directly to the affected part of the brain.

The rabbits that received this treatment showed marked progress as compared to those who received saline or NAC alone without the targeted drug delivery, though benefits were seen in both groups that received medication.

“This is an exciting breakthrough and it certainly points toward new hope for those affected by cerebral palsy,” said Rangaramanujam Kannan, a chemical engineer at Wayne State University who worked on the study. “More questions need to be answered, but the potential is immense.”

To read more about Cerebral Palsy, please click on the above title.

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Wednesday, April 18, 2012

Pill Reduced Number of Multiple Sclerosis Lesions in Phase II Trial


ScienceDaily (Apr. 16, 2012)An investigational oral drug called ONO-4641 reduced the number of lesions in people with multiple sclerosis (MS), according to the results of a phase two clinical trial to be presented as Emerging Science (formerly known as Late-Breaking Science) at the American Academy of Neurology's 64th Annual Meeting in New Orleans April 21 to April 28, 2012.

For the study, 407 people between the ages of 18 and 55 with relapsing-remitting MS were randomly given placebo, 0.05 mg, 0.10 mg, or 0.15 mg of ONO-4641 once per day for 26 weeks. People were included in the study if they had two or more relapses in the two years prior to the study, one or more relapses within the year prior to the study or one or more new MS-related brain lesions, also known as Gd-enhancing lesions, detected on MRI within three months prior to the study. Brain scans were performed every four weeks from 10 to 26 weeks.

At the end of the study, people taking 0.05, 0.10, or 0.15 mg of ONO-4641 had 82 percent, 92 percent and 77 percent fewer Gd-enhancing brain lesions, respectively, compared to placebo.

TO read more about MS, please click on the above title.

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Tuesday, April 17, 2012

Girls May Have Built-In Autism Defenses


Disability Scoop (April 13, 2012)-Autism is nearly five times more common in boys than girls. Now, new research suggests that gender differences could be key to understanding how to treat the disorder.

An international team of scientists analyzing the genetic makeup of more than 1,600 people with autism has identified a gene known as SHANK1 that when mutated, may be responsible for triggering some cases of autism.

Most significantly, however, they found a single family where six individuals carried the gene alteration. The four male family members with the variance all had autism, while two women were unaffected by the developmental disorder despite having the mutation.

The findings reported online Thursday in The American Journal of Human Genetics may help explain why autism is more common in males than females and lead to treatment options, the researchers said.

“This study indicates that there may be a protective factor preventing these female carriers from developing ASD,” said Stephen Scherer of The Hospital for Sick Children in Toronto who was one of the study authors. “(This) protective factor may one day be used to prevent or treat the disorder.”
To read more about autism, please click on the above title.
To access the CDR Library catalog, please click on this link.

Family Connection of SC - Annual Benefit and Auction

image of FC of SC logo
Please join us for an Evening of Hopes & Dreams - a Gala and Auction to Benefit Family Connection of SC
Saturday, April 28
6pm
Chickawa Outdoor Center
Saluda River Club
Lexington, SC

The evening will feature a silent auction full of exciting vacation destinations, restaurant packages, one of kind artwork, show tickets, and much more!
Heavy hors d'oeuvres will be provided by The Blue Marlin!
The evening will include cocktails and dancing in addition to the great auction items and delicious food!

NOTE: To read more about the auction, view a list of auction items, or get a ticket, click on the title above.
NOTE: To access the Center for Disability Resources Library, click on this link.