ScienceDaily (Mar. 19, 2009) — Doctors may be able to tailor a specialized form of brain surgery to more closely match the needs of Parkinson patients, according to results from the first large-scale effort to compare the two current target areas of deep brain stimulation surgery, or DBS.
Called the COMPARE Trial, the National Institutes of Health-funded study conducted at the University of Florida evaluated 45 patients for mood and cognitive changes related to DBS.
UF investigators found that DBS in either brain target effectively treated motor symptoms such as tremors, stiffness and slowness.
However, DBS also produced unique effects depending on the target location, especially in patients' moods and mental sharpness.
The discoveries, in the March 13, 2009 issue of Annals of Neurology, may have an impact on the selection of DBS patients, especially those with pre-existing memory, cognitive or mood disabilities.
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