ScienceDaily (June 24, 2009) — Dr. Jennifer C Palmer and colleagues at the University of Bristol have discovered that endothelin converting enzyme-2 (ECE-2) may cause the decrease in cerebral blood flow seen in Alzheimer's disease.
Alzheimer's disease is the most common form of dementia. Aβ peptide, which accumulates in the brain of Alzheimer's disease patients, is thought to lead to tightening of the blood vessels and reduction of cerebral blood flood. ECE-2 may contribute to these symptoms by converting an inactive precursor to endothelin-1, which constricts blood vessels.
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