Monday, July 27, 2009

Potential New Drug Target For Diabetes And Alzheimer's Disease

Hunin clip art
A single dose of Humanin near-normalizes diabetic levels of glucose in a rat model for type 2 diabetes mellitus. (Credit: Albert Einstein College of Medicine)

ScienceDaily (July 23, 2009) — A cellular protein that may prevent nerve cells from dying also helps to improve insulin action and lower blood glucose levels, according to a study by researchers at Albert Einstein College of Medicine of Yeshiva University in collaboration with scientists at University of California, Los Angeles (UCLA).

The study, which focuses on diabetic rodents, appears this month in PLoS One and is the first to show a role in glucose metabolism for humanin, a small protein (peptide). The researchers also demonstrated that humanin resembles the peptide leptin by acting on the brain to influence glucose metabolism.

Humanin is found in mitochondria — structures that populate the cytoplasm of cells and provide them with energy. The peptide was first detected in brain nerve cells in 2001, and subsequent studies suggest that it protects nerve cells from death associated with Alzheimer's and other brain disease.

To view entire article, please click on the link above.
A single dose of Humanin near-normalizes diabetic levels of glucose in a rat model for type 2 diabetes mellitus. (Credit: Albert Einstein College of Medicine)

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